NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells.

ABSTRACT: Combination therapies or multi-targeted drugs have been pointed out as an option to prevent the emergence of resistant clones, which could make long-term treatment more effective and translate into better clinical outcomes for cancer patients. The NT157 compound is a synthetic tyrphostin that leads to long-term inhibition of IGF1R/IRS1-2-, STAT3- and AXL-mediated signaling pathways. Given the importance of these signaling pathways for the development and progression of lung cancer, this disease becomes an interesting model for generating preclinical evidence on the cellular and molecular mechanisms underlying the antineoplastic activity of NT157. In lung cancer cells, exposure to NT157 decreased, in a dose-dependent manner, cell viability, clonogenicity, cell cycle progression and migratio

SUBMITTER: de Miranda LBL 

PROVIDER: S-EPMC9556623 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature