Exploring the association between cognitive decline and all-cause mortality with blood pressure as a potential modifier in oldest old individuals.

ABSTRACT: Few studies have systematically explored the association between cognitive decline and all-cause mortality among oldest old individuals (above 80 years old), and there is limited evidence of blood pressure (BP) as a potential effect modifier. Therefore, this study included 14,891 oldest old individuals (mean age: 90.3 ± 7.5 years); 10,904 deaths and 34,486 person-years were observed. Cognitive scores were calculated using the Chinese version of the Mini-Mental State Examination (MMSE). Cognitive decline was stratified into ten categories (C0-C9). Continuous cognitive scores were used to assess the interactions of modifiers of the cognitive decline and all-cause mortality association and potentially modifiable factors. Potential effect modifiers were explored by age, sex, BP status and hype

SUBMITTER: Duan J 

PROVIDER: S-EPMC9556626 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature