Risk and prognosis of second corpus uteri cancer after radiation therapy for pelvic cancer: A population-based analysis.

ABSTRACT:

Background

Radiation therapy (RT) is a standard treatment for the local control of primary pelvic cancers (PPC), yet the risk of second corpus uteri cancer (SCUC) in PPC patients undergoing RT is still controversial. This study investigated the impact of RT on the risk of SCUC and assessed the survival outcome.

Methods

We queried nine cancer registries for PPC cases in the Surveillance, Epidemiology, and End Results (SEER) database. The cumulative incidence of SCUC was analyzed using Cox regression and Fine-Gray competing risk regression analysis. The Poisson regression analysis was employed to assess the standardized incidence ratios (SIRs) and radiation-attributed risk (RR) for SCUC. We evaluated the overall survival of patients with SCUC using the Kaplan-Meier method.

SUBMITTER: Yu G 

PROVIDER: S-EPMC9556627 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature