A subtype of institutionalized patients with schizophrenia characterized by pronounced subcortical and cognitive deficits.

ABSTRACT: Some patients with schizophrenia have severe cognitive impairment and functional deficits that require long-term institutional care. The patterns of brain-behavior alterations in these individuals, and their differences from patients living successfully in the community, remain poorly understood. Previous cognition-based studies for stratifying schizophrenia patients highlight the importance of subcortical structures in the context of illness heterogeneity. In the present study, subcortical volumes from 96 institutionalized patients with long-term schizophrenia were evaluated using cluster analysis to test for heterogeneity. These data were compared to those from two groups of community-dwelling individuals with schizophrenia for comparison purposes, including 68 long-term ill and 126 firs

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC9556672 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature