Estrus cycle-dependent working memory effects of prefrontal cortex corticotropin-releasing factor neurotransmission.

ABSTRACT: The prefrontal cortex (PFC) supports a diversity of cognitive processes. Impairment in PFC-dependent cognition is associated with multiple psychiatric disorders, including those known to display sex differences. Our ability to treat this impairment is limited, in part due to an incomplete understanding of the neural mechanisms that support PFC-dependent cognition. In previous studies in male rats, we demonstrated that corticotropin-releasing factor (CRF) receptors and neurons in caudal dorsomedial PFC (dmPFC) regulate PFC-dependent working memory. Subcortically, CRF can exert sex-specific actions, a subset of which are ovarian steroid dependent. To date, the cognitive actions of dmPFC CRF neurotransmission in females are unknown. To address this gap, the current studies examined the effect

SUBMITTER: Berridge CW 

PROVIDER: S-EPMC9556710 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature