Acute stress induces an inflammation dominated by innate immunity represented by neutrophils in mice.

ABSTRACT: It is well known that psychological stress could affect the immune system and then regulate the disease process. Previous studies mostly focused on the effects of chronic stress on diseases and immune cells. How acute stress affects the immune system remains poorly understood. In this study, after 6 hours of restraint stress or no stress, RNA was extracted from mouse peripheral blood followed by sequencing. Through bioinformatics analysis, we found that when compared with the control group, differentially expressed genes in the stress group mainly displayed up-regulated expression. Gene set enrichment analysis results showed that the enriched gene terms were mainly related to inflammatory response, defense response, wounding response, wound healing, complement activation and pro-inflammato

SUBMITTER: Tang L 

PROVIDER: S-EPMC9556762 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature