P2X7 purinergic receptor plays a critical role in maintaining T-cell homeostasis and preventing lupus pathogenesis.

ABSTRACT: The severe lymphoproliferative and lupus diseases developed by MRL/lpr mice depend on interactions between the Fas ^lpr mutation and MRL genetic background. Thus, the Fas ^lpr mutation causes limited disease in C57BL/6 mice. We previously found that accumulating B220⁺ CD4^-CD8^- double negative (DN) T cells in MRL/lpr mice show defective P2X7 receptor ( P2X7)-induced cellular functions, suggesting that P2X7 contributes to T-cell homeostasis, along with Fas. Therefore, we generated a B6/lpr mouse strain (called B6/lpr-p2x7KO) carrying homozygous P2X7 knockout alleles. B6/lpr-p2x7KO mice accumulated high numbers of FasL-expressing B220⁺ DN T cells of CD45RB^high

SUBMITTER: Mellouk A 

PROVIDER: S-EPMC9556828 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature