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Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134.

ABSTRACT: Five new polyketides named alternafurones A (1) and B (2), alternapyrones M-O (3-5), together with fourteen known ones (6-19), were isolated from the desert-plant-derived fungus Alternaria sp. HM 134. The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses. Alternafurones A and B represent polyketides with an unprecedented 6/5/6 skeleton core. Compounds 1, 2 and 4 showed definite inhibitory activities against isocitrate dehydrogenase 1 gene (IDH1 R132h) with IC₅₀ values of 29.38, 19.41 and 14.14 μg/ml, respectively. Seven compounds (6, 7, 9-12, 14) showed potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC₅₀ values ranging from 0.97 μg/ml to 89.80 μg/ml.

SUBMITTER: Li Z

PROVIDER: S-EPMC9556845 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134.

Li Zhuang Z Meng Lu L Ma Qingyun Q Wang Zhen Z Zhao Youxing Y Luo Duqiang D

Frontiers in microbiology 20220929

Five new polyketides named alternafurones A (1) and B (2), alternapyrones M-O (3-5), together with fourteen known ones (6-19), were isolated from the desert-plant-derived fungus Alternaria sp. HM 134. The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses. Alternafurones A and B represent polyketides with an unprecedented 6/5/6 skeleton core. Compounds 1, 2 and 4 showed defin ...[more]

PMID: 36246217

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