New regulatory gene that contributes to control of Bacteroides thetaiotaomicron starch utilization genes.

ABSTRACT: Bacteroides thetaiotaomicron uses starch as a source of carbon and energy. Early steps in the pathway of starch utilization, such as starch binding and starch hydrolysis, are encoded by sus genes, which have been characterized previously. The sus structural genes are expressed only if cells are grown in medium containing maltose or higher oligomers of glucose. Regulation of the sus structural genes is mediated by SusR, an activator that is encoded by a gene located next to the sus structural genes. A strain with a disruption in susR cannot grow on starch but can still grow on maltose and maltotriose. A search for transposon-generated mutants that could not grow on maltose and maltotriose unexpectedly located a gene, designated malR, which regulates expression of an alpha-glucosidase not co

SUBMITTER: Cho KH 

PROVIDER: S-EPMC95569 | biostudies-literature | 2001 Dec

REPOSITORIES: biostudies-literature