Recognition of driver genes with potential prognostic implications in lung adenocarcinoma based on H3K79me2.

ABSTRACT: Lung adenocarcinoma is a malignancy with a low overall survival and a poor prognosis. Studies have shown that lung adenocarcinoma progression relates to locus-specific/global changes in histone modifications. To explore the relationship between histone modification and gene expression changes, we focused on 11 histone modifications and quantitatively analyzed their influences on gene expression. We found that, among the studied histone modifications, H3K79me2 displayed the greatest impact on gene expression regulation. Based on the Shannon entropy, 867 genes with differential H3K79me2 levels during tumorigenesis were identified. Enrichment analyses showed that these genes were involved in 16 common cancer pathways and 11 tumors and were target-regulated by trans-regulatory elements,

SUBMITTER: Zhang LQ 

PROVIDER: S-EPMC9556929 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature