Carpal tunnel surgery dampens thalamocortical and normalizes corticocortical functional connectivity.

ABSTRACT: Carpal tunnel syndrome is the most common entrapment neuropathy and is associated with altered brain function and structure. However, little is understood of the central mechanisms associated with its pain, symptom presentation, and treatment-related resolution. This longitudinal study evaluated carpal tunnel syndrome-related alterations in brain network communication and relationships to behavioural signs of central sensitization before and after carpal tunnel release surgery. We tested the hypothesis that carpal tunnel syndrome is associated with condition- and treatment-related plasticity in brain regions involved in somatosensation. We used quantitative sensory testing and clinical and pain questionnaires to assess sensory and pain function in 25 patients with carpal tunnel syndrome be

SUBMITTER: Osborne NR 

PROVIDER: S-EPMC9556937 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature