Significant difference of differential expression pyroptosis-related genes and their correlations with infiltrated immune cells in sepsis.

ABSTRACT:

Background

Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized by inflammatory cytokine secretion. Recently, an increasing number of studies have investigated the relationship between sepsis and pyroptosis. Appropriate pyroptosis can help to control infection during sepsis, but an immoderate one may cause immune disorders. The present study aimed to identify pyroptosis-related gene biomarkers and their relationship with the immune microenvironment using the genome-wide technique.

Methods

The training dataset GSE154918 and the validation dataset GSE185263 were downloaded for bioinformatics analysis. Differentially expressed pyroptosis-related genes (DEPRGs) were id

SUBMITTER: Wang L 

PROVIDER: S-EPMC9556990 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature