Synthesis, docking studies, biological activity of carbon monoxide release molecules based on coumarin derivatives.

ABSTRACT: In the present work, we synthesized seven complexes. All complexes were identified by ESI-HRMS, ¹H-NMR, ¹⁹F-NMR and ¹³C-NMR spectroscopies. The synthesized complexes were tested for their anticancer activities in vitro against three different human cell lines, including breast MDAMB231, cervical Hela, liver HepG2. IC₅₀ values of complexes 1-7 were 34.98-667.35 µM. Complex 5 revealed higher sensitivity towards MDAMB231 cells with IC₅₀ values 34.98 μM in comparison to 5-FU as positive control. Moreover, complex 5 caused a decrease of mitochondrial membrane potential and effectively induced ROS production against MDAMB231 cells. Western blot analysis showed that complex 5 could up-regulate the expression of Bax protein and down-reg

SUBMITTER: Liu H 

PROVIDER: S-EPMC9557063 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature