Determining biomarkers for evaluation and diagnosis of hereditary angioedema.

ABSTRACT:

Rationale

Kallikrein-bradykinin-forming cascade is known to cause hereditary angioedema (HAE) acute angioedema (AE) attacks. Further research of HAE attacks is needed to explain disease heterogeneity, predict treatment response and identify biomarkers for monitoring HAE attacks. Differential expression of the microvascular endothelial cell-surface receptors for example, g-C1qR, cytokeratin-1, and plasminogen-activator-urokinase-receptor (PLAUR) were hypothesized as biomarkers of AE attacks.

Method

To understand HAE attacks, the differentially expressed genes (DEGs) in RNAseq and mi-RNAseq data of total RNA extracted from skin biopsies of lesional versus non-lesional skin collected during and between attacks in Type-1 HAE patients (n = 11; F:M = 8:3) were compared. To

SUBMITTER: Singh U 

PROVIDER: S-EPMC9557132 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature