Left atrial appendage occlusion in ventricular assist device patients to decrease thromboembolic events: A computer simulation study.

ABSTRACT: Atrial fibrillation (AF) is a common comorbidity in left ventricular assist device (LVAD) patients and has been identified as a risk factor for thromboembolic stroke. Blood stagnation within the left atrial appendage (LAA) is considered a possible major source of thrombosis and clinical studies have shown reduced thromboembolic risk after LAA occlusion (LAAO). Therefore, this study aims to investigate the effect of LAAO on thrombosis-related parameters using patient-specific simulations. Left ventricular and left atrial geometries of an LVAD patient were obtained from computed tomography and combined with hemodynamic data with either sinus rhythm (SR) or AF generated by a lumped parameter model. In four simulations applying contractile walls, stagnation volume and blood residence times wer

SUBMITTER: Ghodrati-Misek M 

PROVIDER: S-EPMC9557157 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature