Hydrogel co-loading SO₂ prodrug and FeGA nanoparticles for enhancing chemodynamic therapy by photothermal-triggered SO₂ gas therapy.

ABSTRACT: Chemodynamic therapy (CDT) is an effective anti-tumor method, while CDT alone cannot achieve a good therapeutic effect. Moreover, the overexpression of glutathione (GSH) in tumor cells dramatically limits the efficiency of CDT. Here, we proposed a hydrogel co-loading SO₂ prodrug and FeGA nanoparticles (NPs) for enhancing CDT by photothermal-triggered SO₂ gas therapy (FBH) system by mixing benzothiazolyl sulfonates (BTS) and FeGA NPs in a certain ratio and encapsulating them in a heat-sensitive hydrogel. FeGA NPs could accelerate the release of Fe²⁺ under acidic conditions and light, and combine with excess H₂O₂ in the tumor for chemokinetic treatment. BTS, as a water-soluble prodrug of SO₂, can accurately control the release

SUBMITTER: Huang Q 

PROVIDER: S-EPMC9557173 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature