Cytotoxic mixed-ligand complexes of Cu(II): A combined experimental and computational study.

ABSTRACT: Herein, we report the synthesis of mixed-ligand Cu(II) complexes of metformin and ciprofloxacin drugs together with 1,10-phenanthroline as a co-ligand. The synthesized complexes were characterized using different spectroscopic and spectrometric techniques. In vitro cytotoxic activity against human breast adenocarcinoma cancer cell line (MCF-7) as well as antibacterial activity against two gram-negative and two gram-positive bacterial strains were also investigated. The analyses of the experimental results were supported using quantum chemical calculations and molecular docking studies against estrogen receptor alpha (ERα; PDB: 5GS4). The cytotoxicity of the [Cu(II) (metformin) (1,10-phenanthroline)] complex (1), with IC₅₀ of 4.29 µM, and the [Cu(II) (ciprofloxacin)

SUBMITTER: Alem MB 

PROVIDER: S-EPMC9557196 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature