Myeloid-derived suppressor cells and vaccination against pathogens.

ABSTRACT: It is widely accepted that the immune system includes molecular and cellular components that play a role in regulating and suppressing the effector immune response in almost any process in which the immune system is involved. Myeloid-derived suppressor cells (MDSCs) are described as a heterogeneous population of myeloid origin, immature state, with a strong capacity to suppress T cells and other immune populations. Although the initial characterization of these cells was strongly associated with pathological conditions such as cancer and then with chronic and acute infections, extensive evidence supports that MDSCs are also involved in physiological/non-pathological settings, including pregnancy, neonatal period, aging, and vaccination. Vaccination is one of the greatest public health achi

SUBMITTER: Prochetto E 

PROVIDER: S-EPMC9557202 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature