Genomic landscape of lung adenocarcinomas in different races.

ABSTRACT:

Background

Lung adenocarcinoma is a molecularly heterogeneous disease. Several studies, including The Cancer Genome Atlas Research Network (TCGA) and Lung Cancer Mutation Consortium (LCMC), explored the genetic alterations among different ethnic groups. However, minority groups are often under-represented in these relevant studies and the genomic alterations among racial groups are not fully understood.

Methods

We analyze genomic characteristics among racial groups to understand the diversities and their impact on clinical outcomes.

Results

Native Americans had significantly higher rates of insertions and deletions than other races (P<0.001). Among patients with lung adenocarcinomas, EGFR and KRAS were the highest discrepancy genes in the different racial groups (P<0.

SUBMITTER: Shi H 

PROVIDER: S-EPMC9557241 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature