Real clinical experience after one year of treatment with tolvaptan in patients with autosomal dominant polycystic kidney disease.

ABSTRACT:

Background

Tolvaptan (TV) is the first vasopressin-receptor antagonist approved for the treatment of autosomal dominant polycystic kidney disease (ADPKD). No publications report TV experience in real clinical practice during the first year of treatment.

Methods

A prospective study of an initial cohort of 220 rapidly progressing patients treated with TV for 12 months. The tolerability of TV, the evolution of the estimated glomerular filtration rate (eGFR), analytical parameters, and blood pressure were analyzed.

Results

A total of 163 patients (78.2%) received TV for 1 year. The main causes of treatment withdrawal were the aquaretic effects (11%), eGFR deterioration (5%), and hepatic toxicity (2.3%). eGFR decreased significantly after 1 month of treatment without furth

SUBMITTER: Naranjo J 

PROVIDER: S-EPMC9557750 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature