Case fatality risk of diarrhoeal pathogens: a systematic review and meta-analysis.

ABSTRACT:

Background

Estimates of the relative contribution of different pathogens to all-cause diarrhoea mortality are needed to inform global diarrhoea burden models and prioritize interventions. We aimed to investigate and estimate heterogeneity in the case fatality risk (CFR) of different diarrhoeal pathogens.

Methods

We conducted a systematic review and meta-analysis of studies that reported cases and deaths for 15 enteric pathogens published between 1990 and 2019. The primary outcome was the pathogen-specific CFR stratified by age group, country-specific under-5 mortality rate, setting, study year and rotavirus vaccine introduction status. We developed fixed-effects and multilevel mixed-effects logistic regression models to estimate the pooled CFR overall and for each pathogen,

SUBMITTER: Asare EO 

PROVIDER: S-EPMC9557849 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature