Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner.

ABSTRACT:

Summary statement

Diabetic human and murine retinas revealed pronounced microglial morphological activation and vascular abnormalities associated with inflammation. Pharmacological fibrinogen depletion using ancrod dampened microglial morphology alterations, resolved fibrinogen accumulation, rescued axonal integrity, and reduced inflammation in the diabetic murine retina.

SUBMITTER: Sarker B 

PROVIDER: S-EPMC9557863 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature