An immuno-score signature of tumor immune microenvironment predicts clinical outcomes in locally advanced rectal cancer.

ABSTRACT:

Background and purpose

Accumulating evidence indicates that neoadjuvant chemoradiotherapy(nCRT) success has an immune-associated constituent in locally advanced rectal cancer (LARC). The immune-associated configuration of the tumor microenvironment associated with responses to treatment was explored in LARC in this study.

Material and methods

A novel analytic framework was developed based on within-sample relative expression orderings for identifying tumor immune-associated gene pairs and identified an immuno-score signature from bulk transcriptome profiling analysis of 200 LARC patients. And sequencing and microarray analysis of gene expression was conducted to investigate the association between the signature and response to nCRT, immunotherapy, and cell function of CD4 an

SUBMITTER: Xue Z 

PROVIDER: S-EPMC9558072 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature