Directed Ni-Catalyzed Reductive Arylation of Aliphatic C-H Bonds.

ABSTRACT: Herein, we describe the nickel-catalyzed reductive arylation of remote C(sp³)-H bonds with aryl electrophiles. The reaction targets secondary and tertiary C(sp³)-H bonds to deliver all-carbon quaternary centers. The success of this method relies on a novel amidyl radical precursor that tolerates reducing conditions, namely O-oxalate hydroxamic acid esters.

SUBMITTER: Liu ZY 

PROVIDER: S-EPMC9558148 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature