C-bouton components on rat extensor digitorum longus motoneurons are resistant to chronic functional overload.

ABSTRACT: Mammalian motor systems adapt to the demands of their environment. For example, muscle fibre types change in response to increased load or endurance demands. However, for adaptations to be effective, motoneurons must adapt such that their properties match those of the innervated muscle fibres. We used a rat model of chronic functional overload to assess adaptations to both motoneuron size and a key modulatory synapse responsible for amplification of motor output, C-boutons. Overload of extensor digitorum longus (EDL) muscles was induced by removal of their synergists, tibialis anterior muscles. Following 21 days survival, EDL muscles showed an increase in fatigue resistance and a decrease in force output, indicating a shift to a slower phenotype. These changes were reflected by a decrease

SUBMITTER: Kissane RWP 

PROVIDER: S-EPMC9558151 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature