Exposure to the <i>Pseudomonas aeruginosa</i> secretome alters the proteome and secondary metabolite production of <i>Aspergillus fumigatus</i>.

ABSTRACT: The fungal pathogen Aspergillus fumigatus is frequently cultured from the sputum of cystic fibrosis (CF) patients along with the bacterium Pseudomonas aeruginosa. A. fumigatus secretes a range of secondary metabolites, and one of these, gliotoxin, has inhibitory effects on the host immune response. The effect of P. aeruginosa culture filtrate (CuF) on fungal growth and gliotoxin production was investigated. Exposure of A. fumigatus hyphae to P. aeruginosa cells induced increased production of gliotoxin and a decrease in fungal growth. In contrast, exposure of A. fumigatus hyphae to P. aeruginosa CuF led to increased growth and decreased gliotoxin production. Quantitative proteomic analysis was used to characterize the proteomic response of <

SUBMITTER: Margalit A 

PROVIDER: S-EPMC9558348 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature