Analysis of antibiotic use and clinical outcomes in adults with known and suspected pleural empyema.

ABSTRACT:

Background

There is not a prevailing consensus on appropriate antibiotic choice, route, and duration in the treatment of bacterial pleural empyema after appropriate source control. Professional society guidelines note the lack of comparative trials with which to guide recommendations. We assessed clinical outcomes in the treatment of known and suspected empyema based upon three aspects of antibiotic use: (1) total duration, (2) duration of intravenous (IV) antibiotics, and (3) duration of anti-anaerobic antibiotics.

Methods

We performed a hypothesis-generating retrospective chart review analysis of 355 adult inpatients who had pleural drainage, via either chest tube or surgical intervention, for known or suspected empyema. The primary outcome variable was clinician assessmen

SUBMITTER: Avner BS 

PROVIDER: S-EPMC9558363 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature