The important role of NLRP6 inflammasome in Pasteurella multocida infection.

ABSTRACT: Pasteurella multocida (P. multocida) can cause severe respiratory disease in cattle, resulting in high mortality and morbidity. Inflammasomes are multiprotein complexes in the cytoplasm that recognize pathogens and play an important role in the host defense against microbial infection. In this study, the mechanism of P. multocida-induced NLRP6 inflammasome activation was investigated in vitro and in vivo. Firstly, P. multocida induced severe inflammation with a large number of inflammatory cells infiltrating the lungs of WT and Nlrp6^-/- mice. Nlrp6^-/- mice were more susceptible to P. multocida infection and they had more bacterial burden in the lungs. Then, the recruitment of macrophages and neutrophils in the lungs was investigated and the results show that the numbe

SUBMITTER: Wu X 

PROVIDER: S-EPMC9558406 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature