RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression.

ABSTRACT:

Background

NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key player in regulating lipid homeostasis in the liver and adipose tissues by using tissue-specific HuR knockout mice. However, the underlying mechanism by which hepatocyte-specific HuR regulates hepatic lipid metabolism under metabolic stress remains unclear and is the focus of this study.

Methods

Hepatocyte-specific HuR deficient mice (HuR^hKO) and age-/gender-matched control mice, as well as long-noncoding RNA H19 knockout mice (H19^-/-), were fed a Western Diet plus sugar water (WDSW). Hepatic lipid accumulation, inflammation and fibrosis were examined by

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9558407 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature