Correlation between insulin-based and C-peptide based homeostatic model assessment of insulin resistance in adults without diabetes in a sub-Saharan African setting: a cross-sectional study.

ABSTRACT:

Objective

To assess the correlation between the insulin-based and C-peptide based HOMA-IR in the general population without diabetes in sub-Saharan Africa as well as to identify factors associated with IR.

Results

This was a cross-sectional study in urban settings in Yaoundé, Cameroon. We included 84 people with a body mass index (BMI) ≥ 18.5 Kg/m² and without diabetes (females: 72.6%; mean age: 37 years). IR was assessed using the following formulae: HOMA-IR_INS = fasting insulin (mU/ml) x fasting plasma glucose (FPG) (mmol/L)/ 22.5; HOMA-IR_CP1 = fasting C-peptide (mU/ml) x FPG (mmol/L)/ 22.5; and HOMA-IR_CP2 = 1.5 + (FPG (mg/dl) x fasting C-peptide (ng/ml))/ 2800. Correlation (rho) between HOMA-IR_INS and C-peptide based HOMA-IR was

SUBMITTER: Tekoh BN 

PROVIDER: S-EPMC9558417 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature