PGE₂ promotes macrophage recruitment and neovascularization in murine wet-type AMD models.

ABSTRACT: Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to the pathogenesis of choroidal neovascularization (CNV) in exudative AMD (wet AMD). This study describes the effects of cyclooxygenase-2 (COX2)/prostaglandin E₂ (PGE₂) signalling on the macrophage activation and CNV formation of wet AMD. In a mouse model of laser-induced wet AMD, the mice received an intravitreal injection of celecoxib (a selective COX2 inhibitor). Optical coherence tomography (OCT), fundus fluorescein angiography (FFA), choroidal histology of the CNV lesions, and biochemical markers were assessed. The level of PGE₂ expression was high

SUBMITTER: Zhan P 

PROVIDER: S-EPMC9558420 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature