The cardioprotective and anti-inflammatory effect of inhaled nitric oxide during Fontan surgery in patients with single ventricle congenital heart defects: a prospective randomized study.

ABSTRACT:

Background

Fontan surgery with cardiopulmonary bypass (CPB) causes tremendous systemic stress and inflammatory responses, affecting postoperative organ function, morbidity, and mortality. Although this reaction triggers partially protective anti-inflammatory responses, it is harmful in patients with single ventricle congenital heart defects. Despite decades of research, an effective anti-inflammatory and stress defense strategy is lacking. This study investigated the influence of inhaled nitric oxide (NO) during CPB on early clinical results, including the duration of postoperative respiratory support as a primary outcome and a panel of laboratory analytes.

Methods

In this study, 115 patients were randomized to the Fontan-NO group (n = 48) and the Fontan group (n = 49). Eigh

SUBMITTER: Kolcz J 

PROVIDER: S-EPMC9558421 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature