Increasing Doses of Blueberry Polyphenols Alters Colonic Metabolism and Calcium Absorption in Ovariectomized Rats.

ABSTRACT:

Scope

Blueberries are rich sources of bioactive polyphenols that may provide health benefits when consumed regularly, leading to their increased marketing as dietary supplements. However, the metabolic changes associated with consuming concentrated doses of purified polyphenols, as may be present in dietary supplements, are unknown, especially when considering the colonic metabolites formed. This study aimed to evaluate the pharmacokinetics of high doses of purified blueberry polyphenols.

Methods and results

5-month old, ovariectomized Sprague-Dawley rats are acutely dosed with purified blueberry polyphenols (0, 75, 350, and 1000 mg total polyphenols per kg body weight (bw)) and ⁴⁵ Ca to measure calcium absorption. Blood and urine are collected for 48 h after dosi

SUBMITTER: Cladis DP 

PROVIDER: S-EPMC9558423 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature