Photocrosslinking of Polyacrylamides Using [2 + 2] Photodimerisation of Monothiomaleimides.

ABSTRACT: The [2 + 2] photocycloaddition of monothiomaleimides (MTMs) has been exploited for the photocrosslinking of polyacrylamides. Polymer scaffolds composed of dimethylacrylamide and varying amounts of d,l-homocysteine thiolactone acrylamide (5, 10, and 20 mol %) were synthesized via free-radical polymerization, whereby the latent thiol functionality was exploited to incorporate MTM motifs. Subsequent exposure to UV light (λ = 365 nm, 15 mW cm^-2) triggered intermolecular crosslinking via the photodimerization of MTM side chains, thus resulting in the formation of polyacrylamide gels. The polymer scaffolds were characterized using Fourier transform infrared spectroscopy, UV-visible spectroscopy, ¹H NMR spectroscopy, and size exclusion chromatography, confirming the occurren

SUBMITTER: Aljuaid M 

PROVIDER: S-EPMC9558485 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature