SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.

ABSTRACT:

Rationale

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 pneumonia. We hypothesize that SARS-CoV-2 causes alveolar injury and hypoxemia by damaging mitochondria in airway epithelial cells (AEC) and pulmonary artery smooth muscle cells (PASMC), triggering apoptosis and bioenergetic impairment, and impairing hypoxic pulmonary vasoconstriction (HPV), respectively.

Objectives

We examined the effects of: A) human betacoronaviruses, SARS-CoV-2 and HCoV-OC43, and individual SARS-CoV-2 proteins on apoptosis, mitochondrial fission, and bioenergetics in AEC; and B) SARS-CoV-2 proteins and mouse hepatitis virus (MHV-1) infection on HPV.

Methods

We used transcriptomic data to identify temporal changes in mitochondrial-relevant gene ontology (GO) path

SUBMITTER: Archer SL 

PROVIDER: S-EPMC9558649 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature