Dual roles of oxostephanine as an Aurora kinase inhibitor and angiogenesis suppressor.

ABSTRACT: The Aurora kinases, including Aurora A, B and C, play critical roles in cell division. They have been found overexpressed in a number of types of cancer and may thus be potential targets in cancer therapy. Several Aurora kinase inhibitors have been identified and developed. Some of these have been used in clinical trials and have exhibited certain efficacy in cancer treatment. However, none of these has yet been applied clinically due to the poor outcomes. Oxostephanine is an aporphine alkaloid isolated from several plants of the genus Stephania. This compound has been reported to inhibit Aurora kinase activity in kinase assays and in cancer cells. The present study aimed to investigate the real‑time effects of oxostephanine extracted from Stephania dielsiana Y.C. Wu leaves on the g

SUBMITTER: Tran TT 

PROVIDER: S-EPMC9558763 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature