Left ventricular assist device bioinformatics identify possible hubgenes and regulatory networks involved in the myocardium of patients with left ventricular assist device.

ABSTRACT:

Objective

The aim of this study was to clarify the changes of myocardial gene expression profile after left ventricular assist device (LVAD) implantation and the related molecular biological significance.

Methods

A thorough bioinformatic analysis to evaluate the changes in gene expression profile in patients pre-LVAD and post-LVAD was conducted. Four relevant gene expression datasets-GSE430, GSE974, GSE21610, and GSE52601 from Gene Expression Omnibus (GEO) database were downloaded. Analysis of GEO2R, Gene Ontology (GO), protein-protein interaction (PPI) were used to determine differentially expressed genes (DEGs) and their function, respectively.

Results

A total of 37 DEGs were identified, including 26 down-regulated and 11 up-regulated genes. The molecular function o

SUBMITTER: Ajmal M 

PROVIDER: S-EPMC9558819 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature