The neuropeptide Y single-nucleotide polymorphism rs16147:T>C moderates the effect of alcohol dependence on depression in male Chinese Han population.

ABSTRACT:

Background

Previous studies suggest that alcohol dependence is associated with depression, however, the effect of alcohol dependence varies from individual to individual, which may be due to different genetic backgrounds. The interactions between alcohol dependence and different gene polymorphisms may finally shape the onset of depression. Neuropeptide Y (NPY), which can maintain homeostasis from high-stress stimulation, may protect individuals from the onset of depression. Here, we explored whether the NPY rs16147:T>C has an association with depression in individuals with alcohol dependence during the period of alcohol dependence withdrawal.

Methods

A total of 455 males with alcohol dependence were recruited. The scale of Michigan Alcoholism Screening Test (MA

SUBMITTER: Wei X 

PROVIDER: S-EPMC9558829 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature