Comorbidity phenotypes and risk of mortality in patients with osteoarthritis in the UK: a latent class analysis.

ABSTRACT:

Background

Osteoarthritis (OA) is a common chronic condition but its association with other chronic conditions and mortality is largely unknown. This study aimed to use latent class analysis (LCA) of 30 comorbidities in patients with OA and matched controls without OA to identify clusters of comorbidities and examine the associations between the clusters, opioid use, and mortality.

Methods

A matched cohort analysis of patients derived from the IQVIA Medical Research Data (IMRD-UK) database between 2000 and 2019. 418,329 patients with newly diagnosed OA were matched to 243,170 patients without OA to identify comorbidity phenotypes. Further analysis investigated the effect of opioid use on mortality in individuals with OA and their matched controls.

Results

The median (

SUBMITTER: Zemedikun DT 

PROVIDER: S-EPMC9559033 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature