Repeatability of Peripapillary OCT Angiography in Neurodegenerative Disease.

ABSTRACT:

Purpose

To assess the repeatability of peripapillary OCT angiography (OCTA) in those with Alzheimer disease (AD), mild cognitive impairment (MCI), Parkinson disease (PD), or normal cognition.

Design

Cross-sectional.

Participants

Patients with a clinical diagnosis of AD, MCI, PD, or normal cognition were imaged. Those with glaucoma, diabetes mellitus, vitreoretinal pathology, and poor-quality images were excluded.

Methods

Each eligible eye of each participant underwent 2 OCTA 4.5 × 4.5-mm peripapillary scans in a single session using a Zeiss Cirrus HD-OCT 5000 with AngioPlex (Carl Zeiss Meditec). The Zeiss software (v11.0.0.29946) quantified measures of perfusion in the radial peripapillary capillary (RPC) plexus in 4 sectors (superior, nasal, inferior, temporal

SUBMITTER: Ma JP 

PROVIDER: S-EPMC9559083 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature