Improving Interpretability in Machine Diagnosis: Detection of Geographic Atrophy in OCT Scans.

ABSTRACT:

Purpose

Manually identifying geographic atrophy (GA) presence and location on OCT volume scans can be challenging and time consuming. This study developed a deep learning model simultaneously (1) to perform automated detection of GA presence or absence from OCT volume scans and (2) to provide interpretability by demonstrating which regions of which B-scans show GA.

Design

Med-XAI-Net, an interpretable deep learning model was developed to detect GA presence or absence from OCT volume scans using only volume scan labels, as well as to interpret the most relevant B-scans and B-scan regions.

Participants

One thousand two hundred eighty-four OCT volume scans (each containing 100 B-scans) from 311 participants, including 321 volumes with GA and 963 volumes without GA.

Me

SUBMITTER: Shi X 

PROVIDER: S-EPMC9559084 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature