Regulation of neuronal excitability by reactive oxygen species and calcium signaling: Insights into brain aging.

ABSTRACT: Altered cognition and inefficient learning and memory are hallmarks of brain aging resulting from many small changes in the structure and function of neurons. One such change is a decrease in excitatory synaptic transmission mediated by glutamate and its binding to the AMPA and NMDA subtypes of glutamate receptors. Why there is decreased glutamatergic transmission in aging is not well understood. Interestingly, in aged excitatory neurons, abnormal calcium homeostasis and energy production are reliably observed. These processes have also been shown to modulate the transport and delivery of glutamate receptors to synapses. Most of these channels are translated in the cell body and must be transported to synapses by molecular motors and then transferred to the synaptic surface for proper func

SUBMITTER: Doser RL 

PROVIDER: S-EPMC9559102 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature