Decreased resting perfusion in precuneus and posterior cingulate cortex predicts tinnitus severity.

ABSTRACT: Functional magnetic resonance imaging has been increasingly used to understand the mechanisms involved in subjective tinnitus; however, researchers have struggled to reach a consensus about a primary mechanistic model to explain tinnitus. While many studies have used functional connectivity of the BOLD signal to understand how patterns of activity change with tinnitus severity, there is much less research on whether there are differences in more fundamental physiology, including cerebral blood flow, which may help inform the BOLD measures. Here, arterial spin labeling was used to measure perfusion in four regions-of-interest, guided by current models of tinnitus, in a sample of 60 tinnitus patients and 31 control subjects. We found global reductions in cerebral perfusion in tinnitus compar

SUBMITTER: Zimmerman BJ 

PROVIDER: S-EPMC9559103 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature