Evolution of interictal spiking during the latent period in a mouse model of mesial temporal lobe epilepsy.

ABSTRACT: Interictal spikes and high-frequency oscillations (HFOs, ripples: 80-200 ​Hz, fast ripples: 250-500 ​Hz) occur in epileptic patients and in animal models of mesial temporal lobe epilepsy (MTLE). In this study, we explored how type 1 and type 2 interictal spikes as well as ripples and fast ripples evolve during the latent period in the hippocampus of pilocarpine-treated mice. Depth EEG recordings were obtained from the hippocampus CA3 subfield of adult male mice (n ​= ​5, P60-P100) starting one day before pilocarpine-induced status epilepticus up to the first spontaneous seizure, the so-called latent period. We found that rates of type 1 (n ​= ​1 655) and type 2 (n ​= ​2 309) interictal spikes were significantly lower during the late phase of the latent period compared to its early and mid

SUBMITTER: Levesque M 

PROVIDER: S-EPMC9559106 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature