Data-based dynamic compartment model: Modeling of E. coli fed-batch fermentation in a 600 m3 bubble column.

ABSTRACT: Mathematical modeling is a powerful and inexpensive approach to provide a quantitative basis for improvements that minimize the negative effects of bioreactor heterogeneity. For a model to accurately represent a heterogeneous system, a flow model that describes how mass is channeled between different zones of the bioreactor volume is necessary. In this study, a previously developed compartment model approach based on data from flow-following sensor devices was further developed to account for dynamic changes in volume and flow rates and thus enabling simulation of the widely used fed-batch process. The application of the dynamic compartment model was demonstrated in a study of an industrial fermentation process in a 600 m3 bubble column bioreactor. The flow model was used to evaluate the m

SUBMITTER: Bisgaard J 

PROVIDER: S-EPMC9559308 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature