EspH interacts with the host active Bcr related (ABR) protein to suppress RhoGTPases.

ABSTRACT: Enteropathogenic Escherichia coli are bacterial pathogens that colonize the gut and cause severe diarrhea in humans. Upon intimate attachment to the intestinal epithelium, these pathogens translocate via a type III secretion system virulent proteins, termed effectors, into the host cells. These effectors manipulate diverse host cell organelles and functions for the pathogen's benefit. However, the precise mechanisms underlying their activities are not fully understood despite intensive research. EspH, a critical effector protein, has been previously reported to disrupt the host cell actin cytoskeleton by suppressing RhoGTPase guanine exchange factors. However, native host proteins targeted by EspH to mediate these activities remained unknown. Here, we identified the active Bcr relat

SUBMITTER: Ramachandran RP 

PROVIDER: S-EPMC9559323 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature