Lesions causing central sleep apnea localize to one common brain network.

ABSTRACT:

Objectives

To characterize the specific brain regions for central sleep apnea (CSA) and identify its functional connectivity network.

Methods

We performed a literature search and identified 27 brain injuries causing CSA. We used a recently validated methodology termed "lesion network mapping" to identify the functional brain network subtending the pathophysiology of CSA. Two separate statistical approaches, the two-sample t-test and the Liebermeister test, were used to evaluate the specificity of this network for CSA through a comparison of our results with those of two other neurological syndromes. An additional independent cohort of six CSA cases was used to assess reproducibility.

Results

Our results showed that, despite lesions causing CSA being heterogeneo

SUBMITTER: Yuan T 

PROVIDER: S-EPMC9559371 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature