Cardiac vagal activity is associated with gut-microbiome patterns in women-An exploratory pilot study.

ABSTRACT:

Introduction

A functional reciprocity between the gut microbiome and vagal nerve activity has been suggested, however, human studies addressing this phenomenon are limited.

Methods

Twenty-four-hour cardiac vagal activity (CVA) was assessed from 73 female participants (aged 24.5 ± 4.3 years). Additionally, stool samples were subjected to 16SrRNA gene analysis (V1-V2). Quantitative Insights Into Microbial Ecology (QIIME) was used to analyse microbiome data. Additionally, inflammatory parameters (such as CRP and IL-6) were derived from serum samples.

Results

Daytime CVA correlated significantly with gut microbiota diversity (r _sp = 0.254, p = 0.030), CRP (r _sp = -0.348, p = 0.003), and IL-6 (r _sp = -0.32

SUBMITTER: Morkl S 

PROVIDER: S-EPMC9559470 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature