Molecular testing for adolescent and young adult central nervous system tumors: A Canadian guideline.

ABSTRACT: The 2021 World Health Organization (WHO) classification of CNS tumors incorporates molecular signatures with histology and has highlighted differences across pediatric vs adult-type CNS tumors. However, adolescent and young adults (AYA; aged 15-39), can suffer from tumors across this spectrum and is a recognized orphan population that requires multidisciplinary, specialized care, and often through a transition phase. To advocate for a uniform testing strategy in AYAs, pediatric and adult specialists from neuro-oncology, radiation oncology, neuropathology, and neurosurgery helped develop this review and testing framework through the Canadian AYA Neuro-Oncology Consortium. We propose a comprehensive approach to molecular testing in this unique population, based on the recent tumor classifica

SUBMITTER: Lim-Fat MJ 

PROVIDER: S-EPMC9559579 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature