Cigarette smoking, coffee consumption, alcohol intake, and clozapine metabolism: A Mendelian randomization study.

ABSTRACT:

Background

Clozapine is an effective antipsychotic medication for patients with treatment-resistant schizophrenia. Previous studies revealed that smoking, alcohol intake, and coffee consumption altered the metabolism of clozapine. However, causal associations between substance use and clozapine levels were not sufficiently established.

Methods

Several genome-wide association studies provided genetic tools for six measures of substance use, including age of smoking, cigarettes per day, smoking cessation, smoking initiation, coffee consumption, and alcohol consumption (GWASs). Utilizing the CLOZUK consortium's dataset, their associations with clozapine and its metabolite concentrations were evaluated. All GWAS data were collected from the European population. Mendelian randomi

SUBMITTER: Zeng L 

PROVIDER: S-EPMC9559606 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature